Implementing a one-step GEE algorithm for very large cluster sizes in R

Posted on March 21, 2023

Very large data sets can present estimation problems for some statistical models, particularly ones that cannot avoid matrix inversion. For example, generalized estimating equations (GEE) models that are used when individual observations are correlated within groups can have severe computation challenges when the cluster sizes get too large. GEE are often used when repeated measures for an individual are collected over time; the individual is considered the cluster in this analysis. [Read More]
R 

simstudy 0.6.0 released: more flexible correlation patterns

Posted on February 21, 2023

The new version (0.6.0) of simstudy is available for download from CRAN. In addition to some important bug fixes, I’ve added new functionality that should make data generation with correlated data a little more flexible. In the previous post, I described enhancements to the function genCorMat. As part of this release announcement, I’m describing blockExchangeMat and blockDecayMat, two new functions that can be used to generate correlation matrices when there is a temporal element to the data generation. [Read More]
R  simstudy  correlated data 

Flexible correlation generation: an update to genCorMat in simstudy

Posted on February 14, 2023

I’ve been slowly working on some updates to simstudy, focusing mostly on the functionality to generate correlation matrices (which can be used to simulate correlated data). Here, I’m briefly describing the function genCorMat, which has been updated to facilitate the generation of correlation matrices for clusters of different sizes and with potentially different correlation coefficients. I’ll briefly describe what the existing function can currently do, and then give an idea about what the enhancements will provide. [Read More]
R  simstudy  correlated data 

A GAM for time trends in a stepped-wedge trial with a binary outcome

Posted on January 17, 2023

In a previous post, I described some ways one might go about analyzing data from a stepped-wedge, cluster-randomized trial using a generalized additive model (a GAM), focusing on continuous outcomes. I have spent the past few weeks developing a similar model for a binary outcome, and have started to explore model comparison and methods to evaluate goodness-of-fit. The following describes some of my thought process. Data generation The data generation process I am using here follows along pretty closely with the earlier post, except, of course, the outcome has changed from continuous to binary. [Read More]
R  Cluster randomized trials  GAM 

Modeling the secular trend in a stepped-wedge design

Posted on December 13, 2022

Recently I started a discussion about modeling secular trends using flexible models in the context of cluster randomized trials. I’ve been motivated by a trial I am involved with that is using a stepped-wedge study design. The initial post focused on more standard parallel designs; here, I want to extend the discussion explicitly to the stepped-wedge design. The stepped-wedge design Stepped-wedge designs are a special class of cluster randomized trial where each cluster is observed in both treatment arms (as opposed to the classic parallel design where only some of the clusters receive the treatment). [Read More]
R  Cluster randomized trials 

Generating clustered data with marginal correlations

Posted on November 22, 2022

A student is working on a project to derive an analytic solution to the problem of sample size determination in the context of cluster randomized trials and repeated individual-level measurement (something I’ve thought a little bit about before). Though the goal is an analytic solution, we do want confirmation with simulation. So, I was a little disheartened to discover that the routines I’d developed in simstudy for this were not quite up to the task. [Read More]
R 

Modeling the secular trend in a cluster randomized trial using very flexible models

Posted on November 1, 2022

A key challenge - maybe the key challenge - of a stepped wedge clinical trial design is the threat of confounding by time. This is a cross-over design where the unit of randomization is a group or cluster, where each cluster begins in the control state and transitions to the intervention. It is the transition point that is randomized. Since outcomes could be changing over time regardless of the intervention, it is important to model the time trends when conducting the efficacy analysis. [Read More]
R  Cluster randomized trials 

Presenting results for multinomial logistic regression: a marginal approach using propensity scores

Posted on September 20, 2022

Multinomial logistic regression modeling can provide an understanding of the factors influencing an unordered, categorical outcome. For example, if we are interested in identifying individual-level characteristics associated with political parties in the United States (Democratic, Republican, Libertarian, Green), a multinomial model would be a reasonable approach to for estimating the strength of the associations. In the case of a randomized trial or epidemiological study, we might be primarily interested in the effect of a specific intervention or exposure while controlling for other covariates. [Read More]
R 

Flexible simulation in simstudy with customized distribution functions

Posted on August 30, 2022

Really, the only problem with the simstudy package (😄) is that there is a hard limit to the possible probability distributions that are available (the current count is 15 - see here for a complete description). However, it turns out that there is more flexibility than first meets the eye, and we can easily accommodate a limitless number as long as you are willing to provide some extra code. [Read More]
R  simulation 

Simulating data from a non-linear function by specifying a handful of points

Posted on August 9, 2022

Trying to simulate data with non-linear relationships can be frustrating, since there is not always an obvious mathematical expression that will give you the shape you are looking for. I’ve come up with a relatively simple solution for somewhat complex scenarios that only requires the specification of a few points that lie on or near the desired curve. (Clearly, if the relationships are straightforward, such as relationships that can easily be represented by quadratic or cubic polynomials, there is no need to go through all this trouble. [Read More]
R  simulation  GAM