https://www.rdatagen.net/tags/instrumental-variable/ Recent content in Instrumental Variable on ouR data generation Hugo en keith.goldfeld@nyumc.org (Keith Goldfeld) keith.goldfeld@nyumc.org (Keith Goldfeld) Tue, 03 Sep 2024 00:00:00 +0000 https://www.rdatagen.net/post/2024-09-03-an-instrumental-variable-study-design-to-estimate-an-effect-size-when-randomization-may-not-be-ethical/ Tue, 03 Sep 2024 00:00:00 +0000keith.goldfeld@nyumc.org (Keith Goldfeld) https://www.rdatagen.net/post/2024-09-03-an-instrumental-variable-study-design-to-estimate-an-effect-size-when-randomization-may-not-be-ethical/ <p>An investigator I frequently consult with seeks to estimate the effect of a palliative care treatment protocol for patients nearing end-stage disease, compared to a more standard, though potentially overly burdensome, therapeutic approach. Ideally, we would conduct a two-arm randomized clinical trial (RCT) to create comparable groups and obtain an unbiased estimate of the intervention effect. However, in this case, it may be considered unethical to randomize patients to a non-standard protocol.</p>